penicillin v การใช้

• In 1957, John C . Sheehan announced that his group had completed the first synthesis of penicillin V ( one of the two most useful forms of the antibiotic ).
• A controlled study ( Garvey, Perlmutter, " et al ", 1999 ) of prophylactic antibiotic treatment of 37 children found that penicillin V did not prevent GABHS infections or exacerbation of other symptoms; however, compliance was an issue in this study.
• After nine years of hard work at the Massachusetts Institute of Technology ( M . I . T . ), he became the first to discover a practical method for synthesizing penicillin V . While achieving total synthesis, Sheehan also produced an intermediate 6-aminopenicillanic acid, which turned out to be the foundation of hundreds of kinds of synthetic penicillin.